Diphtheria, Tetanus, Pertussis, & Hib Vaccine
In Canadian childhood vaccination programs, vaccines against diphtheria, tetanus, pertussis (whooping cough), polio and Haemophilus (a bacterial infection) are administered as one shot in a vaccine with the trade name, Pentacel™. Pediacel™, an alternate vaccine to this, has the same formula except the culture used to grow its polio viruses is monkey tissue rather than the (aborted) human lung tissue used for Pentacel™.
Pentacel™ was formulated when Haemophilus vaccine first became available. Just prior to this, polio vaccine was administered together with diphtheria, tetanus, and pertussis vaccines in a four-valent vaccine or by itself, separate from DTP vaccine. It was serious adverse reactions to DTP vaccine that gave rise to much more wary vaccine consumerism starting in the 1980’s. And despite its use for 70 decades, whooping cough outbreaks still occur in highly vaccinated populations.
With increased vulnerability of babies of mothers who’ve never been exposed to pertussis infections, and increased vulnerability of teens and adults whose childhood vaccinations no longer protect them, pertussis vaccine is now scheduled for most of a Canadian’s lifespan. As well as Pentacel™ or Pediacel™ for infants and children 2 mos to 6 yrs old, Adacel™, containing tetanus, diphtheria and pertussis antigens (pathogenic substances against which the immune system reacts) is given to 12- to 54-year-olds.
Now a third vaccine is being offered as a first shot given to infants. With the addition of a sixth component against hepatitis B, this vaccine, Infanrix hexa™, is hoped to encourage more parents to opt for vaccination. After all, it eliminates one of the four first needles jabbed into pudgy little arms. However, coincidentally, it also may make it even more difficult for parents who wish to consent to only one or two vaccines to do so.
Please see the separate Polio page in the Specific Vaccines section for more articles on this subject.
- Five Vaccines in One: Your Baby’s First Shot (a discussion of the diseases including polio; the Pentacel™ vaccine; potential efficacy; and potential risk)
- Six Vaccines in One: Your Baby’s First Shot (INFANRIX hexa™ product monograph lists 10 immune stimulating biological ingredients: one against each of diphtheria, tetanus, Haemophilus influenzae B and Hepatitis B; three against polio; and three against pertussis)
- Whooping Cough: The Disease and the Vaccine (includes history of whooping cough; risks of the vaccine; and limits to efficacy, with an emphasis on risks)
- A Not-So-Perfect Vaccine: The Diphtheria, Tetanus and Acellular Pertussis Vaccine: An Investigation (a detailed examination of pertussis disease, pertussis vaccine, and a comparison of adverse events from the whole cell pertussis vaccine with those from the newer acellular vaccine)
- The True Story of Pertussis Vaccination: A sordid Legacy? (This 2003 winner of the Jackson prize – awarded for the best article published in the 2000, 2001, and 2002 volumes of Journal of the History of Medicine and Allied Sciences – explores the history of whooping cough vaccination. See JHMAS; July 2002; 57:3 and link to NCBI PubMed.)
- Vaccine Injuries Under-Reported and Ignored (a letter to the Saskatchewan Minister of Health from parents of a young boy neurologically damaged by Pentacel™)
- Pertussis Resurgence in Canada (a science journal excerpt showing that “a poorly protective pertussis vaccine” resulted in a 10-fold increase in the incidence of pertussis)
- A Compilation of Licensed Vaccines in Canada from 1971-2003
- Haemophilus Influenza B, the Disease & the Vaccine
- Changing Disease Epidemiology Via Vaccines – Are We “Robbing Peter To Pay Paul”?
- Breastfeeding Protects from Haemophilus Influenza (medical article references)
- Diabetes Rises in Finland following Haemophilus Influenza B Vaccine (Hib)
- Diphtheria and Tetanus (Dr Sherri Tenpenny dismantles the argument that adults need Td – tetanus and diphtheria combined – shots)
- Tetanus Vaccine in Canada (combination vaccines such as Pentacel™ are now the only tetanus-containing vaccines available)
- Tetanus Toxoid Vaccination (emphasizes risks and includes contraindications and alternate methods of prevention)
- Tetanus (an eye-opening article compiled from several sources)
- Tetanus: Dr. Mendelsohn Discusses the Disease & the Vaccine
- Magnesium as Tetanus Therapy
Links to Other Articles
- National Library of Medicine (a list of articles)
- Trends in Pertussis Among Infants in the United States, 1980-1999 (“Reported cases of pertussis among adolescents and adults have increased since the 1980’s, despite increasingly high rates of vaccination among infants and children. However, severe pertussis mobidity and mortality occur primarily among infants.”)
- Reemergence of Pertussis in the Highly Vaccinated Population of the Netherlands: Observations on Surveillance Data. (“The increase in pertussis incidence was higher among vaccinated than among unvaccinated persons of all ages. This resulted in lower estimates of vaccine effectiveness.”)

